Basic Info.
Grade Standard
Medicine Grade, Tech Grade, Phamaceutical Grade
Transport
Air/Express/Sea
Storage
Keep Cool and Dry
Water Solubility
Freely Soluble in Water
Specification
1g 10g 100g
Product Description
GMP/ISO Manufacturer Rapamycin powder/ Sirolimus 99% CAS 53123-88-9
Quick Details: Product Name | Rapamycin/Sirolimus |
CAS NO. | 53123-88-9 |
Purity | 99% |
Density | 1.182 |
Appearance and shape | White powder |
What is Sirolimus ?
Sirolimus (also known as rapamycin) is a chemical that was discovered by Suren Sehgal,[1] as a product of bacteria discovered on Easter Island (the island is also known as Rapa Nui).[2] It was approved by the US Food and Drug Administration in September 1999 and is marketed under the trade name Rapamune by Pfizer (formerly by Wyeth).
Sirolimus was originally developed as an antifungal agent. However, this use was abandoned when it was discovered to have potent immunosuppressive and antiproliferative properties. It has since been shown to prolong the life of mice and might also be useful in the treatment of certain cancers.
Rapamycin is a triene macrolide antibiotic,which demonstrates anti-fungal,anti-inflammatory,anti-tumor and immunosuppressive properties.
Rapamycin has been shown to block T-cell activation and proliferation,as well as,the activation of p70 S6 kinase and exhibits
strong binding to FK506 binding proteins.
Rapamycin has been shown to block T-cell activation and proliferation,as well as,the activation of p70 S6 kinase and exhibits strong binding to FK506 binding proteins.
Function
It is used to coat coronary stents, prevent organ transplant rejection and to treat a rare lung disease called lymphangioleiomyomatosis. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It inhibits activation of T cells and B cells by reducing the production of interleukin-2 (IL-2).
Application
Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins. Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.
Anti-Tumor |
1 | Pirfenidone | 53179-13-8 |
2 | Gefitinib | 184475-35-2 |
3 | Trabectedin | 114899-77-3 |
4 | Eribulin Mesilate | 441015-17-6 |
5 | Midostaurin | 120685-11-2 |
6 | Everolimus(2.0% BHT) | 159351-69-6 |
7 | Everolimus(without BHT) | 159351-69-6 |
8 | Etoposide | 33419-42-0 |
Shipping Terms |
By Express | By Air | By Sea |
Suitable for under 50kg Fast: 3-7 days Door to door service, easy to pick up the goods | Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed | Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed |
Q1.How to confirm the Product Quality before placing orders?
A. Offering you our products specification standard (tested by HPLC, UV, GC and TLC etc.)
B. Free samples could be sent to check the product quality before ordering.
C. If you have special requirement on the product, we may customize it according to your requirement until to your approval.
Q2: Samples & MOQ
A. We could provide some free samples, but the shipping cost should be on the customers' account. You can either pay the shipping cost or arrange a courier
to collect the samples.
B. For the high value product, our MOQ starts from 1g and generally starts from 10g.For other low value product, our MOQ starts from 1kg.
Q3: How about delivery?
A: Delivery lead time: within 1-2 days when get the payment.
B. Samples: please expect 10-15 days by FedEx,EMS, UPS,TNT..
C. Double customs clearance ,safe delivery ,gurantee receive.
We guarantee that 100% of your parcel passes through the United States, Britain,Canada, Mexico, France, Germany, Spain, Belgium, Sweden, Poland, and Russia. We have powerful customs clearance agencies in these countries, and our customs clearance company will clear your parcel without any customs issues, sometimes even 1000 kg. Door to door service DDP service. To ensure 100% receipt of your package, if there are any customs issues, we are willing to reissue your package free of charge. Let you have a good experience of our strong shipping capabilities.
We have many customers in those countries and retain long-term cooperation. Provide a large number of high-quality products. They made a lot of money. I am sure we can make more money together. There is money to have glory.Contact us for price lists and test reports!
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Address:
Rm.2114, Block A, Jing Kai Wei Lai Cheng, Economic & Technological Dev. Zone, Wuhan, China
Business Type:
Manufacturer/Factory
Business Range:
Chemicals, Health & Medicine, Security & Protection
Management System Certification:
ISO 9001, ISO 9000
Company Introduction:
Wuhan Yiruo Pharmaceutical Technology Co., Ltd. is a global health industry suppliers of nutritional supplement, nootropics, peptides ( raw powder and vials) and other active pharmaceutical materials.
Our company has independent property rights of 1, 000 square meters of R& D centers, 350, 000 square meters of production plants, has a strong R & D team and good-trained production team. We have 50 to 2000 litres of reactors, more than 30 in total, can produce kilograms to tons of various types of organic synthesis and plant extracts related products. We have two patents, four categories trademark and other kinds of certificate.
With great joint efforts of our staffs, Wuhan Yiruo Pharmaceutical is getting more market for developing and manufacturing Medicine, New Compounds, Advanced Intermediates, as well as Custom Synthesis. We will make persistent efforts, providing excellent services to our customers, perfecting R& D condition, as well as enlarging business service range. We believe Yiruo will be one of the brightest star in near future with your kind support and our mutual efforts.